WebFeb 3, 2014 · Coiled-coils represent a special case of protein folding in which formation of the hydrophobic core is coupled to oligomerization (dimerization in this case). We therefore used differential scanning fluorescence thermal melting assays to examine the coupled folding/dimerization transition. Webstranded coiled-coil motif. We introduce a computational method for predicting coiled-coil protein interactions, and give a novel framework that is able to use both genomic se-quence data and experimental data in making these predic-tions. Cross-validation tests show that the method is able to predict many aspects of protein-protein ...
Protein labelling via formation of coiled-coils. (A) Covalent …
WebJun 4, 2015 · The tripartite motif (TRIM) consists of an N-terminal RING domain, one or two B-box domains and a C-terminal coiled-coil domain. The TRIM segment is considered to serve as a scaffold domain... WebNational Center for Biotechnology Information intersect faces
Coiled‐Coil Peptide Beacon: A Tunable Conformational Switch for …
http://www.coiled-coil.org/ WebOne example for high affinity peptide-peptide interactions is the coiled-coil motif, in which helical peptides wrap around each other to form a superhelix. In 1996, Hodges et al. designed a coiled ... A coiled coil is a structural motif in proteins in which 2–7 alpha-helices are coiled together like the strands of a rope. (Dimers and trimers are the most common types.) Many coiled coil-type proteins are involved in important biological functions, such as the regulation of gene expression — e.g., transcription … See more The possibility of coiled coils for α-keratin was initially somewhat controversial. Linus Pauling and Francis Crick independently came to the conclusion that this was possible at about the same time. In the summer of 1952, … See more Coiled coils usually contain a repeated pattern, hxxhcxc, of hydrophobic (h) and charged (c) amino-acid residues, referred to as a heptad repeat. The positions in the heptad repeat are usually labeled abcdefg, where a and d are the hydrophobic positions, often … See more • Crick, FHC (1953). "The Packing of α-Helices: Simple Coiled-Coils". Acta Crystallogr. 6 (8): 689–697. doi: • Nishikawa K, Scheraga HA … See more • Coiled-coil domains of keratins Coiled-coil related software Prediction, detection, and visualization • See more Role in HIV infection Viral entry into CD4-positive cells commences when three subunits of a glycoprotein 120 (gp120) bind to CD4 receptor and a … See more The general problem of deciding on the folded structure of a protein when given the amino acid sequence (the so-called protein folding problem) has only been solved partially. However, the coiled coil is one of a relatively small number of folding motifs for which the … See more intersect feature arcpro