Phosphopantetheine attachment site

Author: mcrs

August undefined, 2024

WebThe human NDUFAB1 protein contains a phosphopantetheine attachment site (DLGLDSLDQVEIIMAM), unique for acyl carrier proteins, and an EF-hand calcium binding domain (DIDAEKLMCPQEI). Transcripts of this gene are found in … WebAug 1, 2015 · Phosphopantetheine attachment site: Dieckmanna Cyclase (DKC) NADB-Rossmann: I3810-R4092: NAD(P)-binding motif: ORF3 (fumoA) encodes a cytochrome P450 monooxygenase which maybe catalyzes an unprecedented oxidative ring expansion of prefumosorinone A to form the 2-pyridone core of fumosorinone (Halo et al., 2008a). …

Phosphopantetheine - an overview ScienceDirect Topics

WebFeb 20, 2024 · In addition, the phosphopantetheinylation of ACPs is dependent on the co-enzyme A, the PPT enzyme and the conserved serine residue in the phosphopantetheine attachment site (Supplementary Fig. 3 ... WebAcp phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Pfam Domain Function. PP-binding ; Transmembrane Regions Not Available Cellular … sonji reddy md san antonio

Acyl carrier protein DrugBank Online

WebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process / acyl binding / lipid binding / phosphopantetheine binding Processes fatty acid biosynthetic process / lipid A biosynthetic process / lipid biosynthetic process / response to drug Components cytoplasm / cytosol General Function WebPhosphopantetheine attachment site Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where … WebSep 2, 2014 · There is a phosphopantetheine attachment site spanning residues G 143 to M 164 in AhDGAT1-1 (G 157 to M 178 in AhDGAT1-2). A putative thiolase acyl-enzyme intermediate binding motif, previously cited in the Arabidopsis sequence by Zou et al. (1999) , is also found in AhDGAT1. It contains an invariant Pro208 at the N-terminus of this motif … sonju from the promised neverland

Integrated Bioinformatics Analysis to Study Gallic Acid ... - Springer

Washington University School of Medicine Digital …

WebPromotional Article Monitoring. Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly. WebPhosphopantetheine attachment site Provide feedback. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. sonjoe 40voltion 14 inch cordless mowerhttp://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00823 sonkach mp pin code

"WebMay 28, 2010 · The amino acid sequence of NDRG1/Cap43 has been reported to bear a phosphopantetheine attachment site, an α/β hydrolase fold and three tandem repeats [15], [19], as well as a few sites that are phosphorylated by SGK [20] (Fig. 1 A). Western blotting revealed that NDRG1/Cap43 protein had several bands with different mobilities, including … " - Phosphopantetheine attachment site

Phosphopantetheine attachment site

PDB 4ihh structure summary ‹ Protein Data Bank in Europe (PDBe) …

Web4'-Phosphopantetheine C11H23N2O7PS CID 115254 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... WebJan 10, 2024 · To obtain active CAR enzyme, a phosphopantetheine group must be attached covalently to a conserved serine in the PCP domain mediated by a suitable …

Did you know?

WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) ( Scheme 23 ), polyketides (PKs) (use ACPs) ( Scheme … WebJul 17, 2024 · The PCP Ser702, which serves as the phosphopantetheine attachment site, is positioned 52 Å away from the bound AMP phosphate. By contrast, ...

WebDec 6, 2013 · For NRPS, the domains are: adenylation (A), condensation (C), oxidation (Ox), thioesterase (Te) and 4-phosphopantetheine attachment site (PP). Figure 3. Alignment of the PKS/NRPS cluster at genomic coordinates of 3092397–3133943 in D. solani D s0432-1 with the two closest homologs in D. zeae Ech586 and T. turnerae T7901. The improved ... WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production.

WebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Alternate IDs None Definition Binding an acyl group and presenting it for processing or … WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier … Hei Sook Sul, ... Li Chen, in Progress in Nucleic Acid Research and Molecular …

WebPhylogenetic analysis of CARs. A) Domain organization of CAR sequences: adenylation domain (PFam PF00501), phosphopantetheine (PP) attachment site (PF00550), reductase domain (PF07793). B)...

WebDownload scientific diagram Phylogenetic analysis of CARs. A) Domain organization of CAR sequences: adenylation domain (PFam PF00501), phosphopantetheine (PP) … small lump on chest under skinWebphosphopantetheine (or pantetheine 4' phosphate) (Ppant) prosthetic group that is covalently attached to an invariant serine residue of the CP domain. CP domains, typically … sonkatch to indoreWebDefinition: Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis. ID: GO:0000036 Synonyms: Articles referencing this term. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork ... sonkatch toll plazaWebMar 21, 2024 · This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ( [ACP]) domain. ( FAS_HUMAN,P49327 ) (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. ( FAS_HUMAN,P49327 ) sonkatch mp pin codeWebApr 26, 2024 · In addition, it showed a close relationship with the phosphopantetheine attachment site protein (IPR006162) and acyl carrier protein of super family SSF47336 (IPR009081). It also shares similarities with the peptide chains of IPR020806 polyketide synthase, phosphopantetheine-binding domain, and others including IPR020845, … sonkaucc.orgWebthis effect was dependent upon an intact phosphopantetheine attachment site (PPAS) motif within the α/β hydrolase fold of NDRG1. Materials and Methods. Cell lines and culture. BeWo, JEG-3, CHO, and NIH3T3 lines were purchased from ATCC (Manassas, VA) and cultured as we previously detailed [38-41]. We also previously characterized and detailed the son jover incaWebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process: Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis. GO:0009987: cellular process small lump just below ear