Tfrc knockin
Web23 Jan 2024 · Background Transferrin receptor 1 (TfR1), encoded by TFRC, is a key regulator of iron homeostasis and plays important roles in many diseases, including cancers. … Web5 Nov 2024 · The IREB2 gene encodes an iron-responsive element-binding protein (IRP) that regulates the expression of proteins involved in iron metabolism by binding to iron-responsive elements in the mRNAs of target genes, which include the transferrin receptor (TFRC; 190010) as well as the heavy and light ferritin chains (FTH1, 134770 and FTL, …
Tfrc knockin
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Web13 May 2024 · Transferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive iron conditions, TFRC is expected to be downregulated via the iron regulatory protein and the iron-responsive element machinery to … Web9 Apr 2024 · TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1. Iron metabolism protein transferrin receptor 1 involves in cervical cancer progression by affecting gene expression and alternative splicing in HeLa cells. Host receptor-targeted therapeutic approach to counter pathogenic New World …
Web2 May 2024 · The TfR-mediated incorporation of JR-141 was confirmed by using human fibroblasts in vitro. When administrated intravenously to hTfR knockin mice or monkeys, … WebTFRC INFORMATION. Proteini. Full gene name according to HGNC. Transferrin receptor. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. TFRC (CD71, p90, TFR1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s).
WebHeLa -TFRC(-/-) is a stable cell line with a homozygous knockout of human TFRC using CRISPR/Cas9. Host Cell. HeLa. Shipping. 1 vial of knockout cell line and 1 vial of wildtype … WebSerum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of …
Web11 Jul 2024 · TFRC encodes the transferrin receptor protein 1 (TFR1, UniProt-P02786) in human, which controls the level of intracellular iron levels. TFR1 imports iron from the …
WebTfrc Constitutive Knockout Inquire CALL: 888.822.6642 + 45 70 23 04 05 (EUROPE and DENMARK) +49 214 50 68 023 (GERMANY) Design Your Own Genetically Engineered … hornsearle property investmentsWeb9 Apr 2024 · Summary. This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for … hornsea wikipediaWeb23 Jan 2024 · To obtain TFRC knockdown cells, short hairpin RNA (shRNA) transfection method was used to transfect it into HeLa cells. The TFRC -shRNA sequence (5ʹ-GCT GGT CAG TTC GTG ATT AAA-3ʹ) was introduced into pGFP-B-RS vectors (Origene, Peking, China), which were digested by BamH I and Hind III enzymes. hornsearle property groupWeb24 Jan 2024 · Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types. Its critical physiological function is highlighted by the embryonic lethal phenotype of Tfr1-knockout (Tfrc -/-) mice and the pathologies of several tissue-specific knockouts. hornsea ukWeb21 Mar 2024 · TFRC (Transferrin Receptor) is a Protein Coding gene. Diseases associated with TFRC include Immunodeficiency 46 and Combined Immunodeficiency.Among its … hornsea yorkshire mapWeb26 Jan 2024 · In contrast to the previously reported hepatocyte Tfrc knockout mice, Tfrc fl/fl;Alb-Cre + mice exhibited slightly, but significantly, decreased hematocrit compared with Tfrc fl/fl;Alb-Cre − controls. Hemoglobin was also significantly reduced in Tfrc fl/fl;Alb-Cre + males, with a similar trend in females (Table 1). Tfrc fl/fl;Alb-Cre + mice also exhibited … hornsey appliance centreWebTransferrin Receptor Protein-1 (TFRC) is a cell surface receptor that binds ferric-iron-loaded transferrin in the bloodstream at high affinity to facilitate iron uptake into cells. TFRC is … hornsey argos opening times